Professor
Dept. of Pediatrics
School of Medicine
+1 628 206-8218
Margaret Feeney, MD is the Edward B. Shaw Professor of Pediatrics in the Division of Pediatric Infectious Diseases and Global Health at UCSF. She directs a research program focused on understanding immunity to malaria, identifying correlates of protective immunity to guide vaccine design, and investigating the impact of prenatal exposure to pathogens on the infant immune response. She provides clinical care to pediatric inpatients at the Benioff Children’s Hospital. She has been a member of the UCSF faculty since 2009, and joined the CSW in 2019 in order to advocate for women in science and clinical careers. She is a member of the Policy and Advocacy Committee.
Joined UCSF: 2009
Joined CSW: 2019
CSW sub-committee: Policy/Advocacy
Publications
Liver stage P. falciparum antigens highly targeted by CD4+ T cells in malaria-exposed Ugandan children.
PLoS pathogens
Post-Artesunate Delayed Hemolysis in Pediatric Malaria Patients in the United States.
Journal of the Pediatric Infectious Diseases Society
Post Artesunate Delayed Hemolysis in Pediatric Patients in the United States.
Journal of the Pediatric Infectious Diseases Society
Gravidity influences distinct transcriptional profiles of maternal and fetal placental macrophages at term.
Frontiers in immunology
Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens.
bioRxiv : the preprint server for biology
Broadly inhibitory antibodies against severe malaria virulence proteins.
bioRxiv : the preprint server for biology
Distinct transcriptional profiles of maternal and fetal placental macrophages at term are associated with gravidity.
bioRxiv : the preprint server for biology
Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria.
Science translational medicine
Rapid reconfiguration of sexual health services in response to UK autochthonous transmission of mpox (monkeypox).
Sexually transmitted infections
In Utero Activation of NK Cells in Congenital CMV Infection.
The Journal of infectious diseases
Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children.
Nature communications
Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America
Demographic and clinical characteristics of confirmed human monkeypox virus cases in individuals attending a sexual health centre in London, UK: an observational analysis.
The Lancet. Infectious diseases
A cytotoxic-skewed immune set point predicts low neutralizing antibody levels after Zika virus infection.
Cell reports
Peripheral Plasmodium falciparum infection in early pregnancy is associated with increased maternal microchimerism in the offspring.
The Journal of infectious diseases
Inhibitory KIR ligands are associated with higher P. falciparum parasite prevalence.
The Journal of infectious diseases
HLA Alleles B*53:01 and C*06:02 Are Associated With Higher Risk of P. falciparum Parasitemia in a Cohort in Uganda.
Frontiers in immunology
Malaria and Early Life Immunity: Competence in Context.
Frontiers in immunology
Exposure to pesticides in utero impacts the fetal immune system and response to vaccination in infancy.
Nature communications
Opsonized antigen activates Vd2+ T cells via CD16/FC?RIIIa in individuals with chronic malaria exposure.
PLoS pathogens
Gravidity-dependent associations between interferon response and birth weight in placental malaria.
Malaria journal
The impact of gravidity, symptomatology and timing of infection on placental malaria.
Malaria journal
The immune response to malaria in utero.
Immunological reviews
Intermittent preventive treatment with dihydroartemisinin-piperaquine and risk of malaria following cessation in young Ugandan children: a double-blind, randomised, controlled trial.
The Lancet. Infectious diseases
In utero priming of highly functional effector T cell responses to human malaria.
Science translational medicine
OV21/PETROC: a randomized Gynecologic Cancer Intergroup phase II study of intraperitoneal versus intravenous chemotherapy following neoadjuvant chemotherapy and optimal debulking surgery in epithelial ovarian cancer.
Annals of oncology : official journal of the European Society for Medical Oncology
862: Gene expression profiling of fetal Hofbauer cells and maternal intervillous macrophages in placental malaria.
American Journal of Obstetrics and Gynecology
865: Malaria exposure in pregnancy: birth outcomes with placental and non-placental malaria infection.
American Journal of Obstetrics and Gynecology
Both inflammatory and regulatory cytokine responses to malaria are blunted with increasing age in highly exposed children.
Malaria journal
The Development of Plasmodium falciparum-Specific IL10 CD4 T Cells and Protection from Malaria in Children in an Area of High Malaria Transmission.
Frontiers in immunology
Vd2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure.
Scientific reports
Sex Disparity in Cord Blood FoxP3+ CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero.
Open forum infectious diseases
Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation.
Malaria journal
Impact of In Utero Exposure to Malaria on Fetal T Cell Immunity.
Trends in molecular medicine
Effective Antimalarial Chemoprevention in Childhood Enhances the Quality of CD4+ T Cells and Limits Their Production of Immunoregulatory Interleukin 10.
The Journal of infectious diseases
Erratum to: B cell sub-types following acute malaria and associations with clinical immunity.
Malaria journal
Dihydroartemisinin-Piperaquine for the Prevention of Malaria in Pregnancy.
The New England journal of medicine
Frequent Malaria Drives Progressive Vd2 T-Cell Loss, Dysfunction, and CD16 Up-regulation During Early Childhood.
The Journal of infectious diseases
Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria.
PLoS pathogens
FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure.
PLoS pathogens
Effector Phenotype of Plasmodium falciparum-Specific CD4+ T Cells Is Influenced by Both Age and Transmission Intensity in Naturally Exposed Populations.
The Journal of infectious diseases
IFN? Responses to Pre-erythrocytic and Blood-stage Malaria Antigens Exhibit Differential Associations With Past Exposure and Subsequent Protection.
The Journal of infectious diseases
Loss and dysfunction of Vd2? ?d T cells are associated with clinical tolerance to malaria.
Science translational medicine
IFN?/IL-10 co-producing cells dominate the CD4 response to malaria in highly exposed children.
PLoS pathogens
Predictors of poor CD4 and weight recovery in HIV-infected children initiating ART in South Africa.
PloS one
Sex differences in HIV RNA level and CD4 cell percentage during childhood.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Impact of tuberculosis cotreatment on viral suppression rates among HIV-positive children initiating HAART.
AIDS (London, England)
Sequence evolution of HIV-1 following mother-to-child transmission.
Journal of virology
Correlates of spontaneous viral control among long-term survivors of perinatal HIV-1 infection expressing human leukocyte antigen-B57.
AIDS (London, England)
Maternal transmission of human immunodeficiency virus escape mutations subverts HLA-B57 immunodominance but facilitates viral control in the haploidentical infant.
Journal of virology
Deficiency of HIV-Gag-specific T cells in early childhood correlates with poor viral containment.
Journal of immunology (Baltimore, Md. : 1950)
A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells.
The Journal of experimental medicine
Absence of detectable viremia in a perinatally HIV-1-infected teenager after discontinuation of antiretroviral therapy.
The Journal of allergy and clinical immunology
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
Nature immunology
Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection.
Journal of virology
HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load.
Journal of virology
HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.
Journal of immunology (Baltimore, Md. : 1950)
HIV and children: the developing immune system fights back.
The West Indian medical journal
Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels.
AIDS (London, England)
Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.
The Journal of experimental medicine
Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities.
Journal of virology
Reconstitution of virus-specific CD4 proliferative responses in pediatric HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950)
Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.
AIDS (London, England)
Comprehensive screening reveals strong and broadly directed human immunodeficiency virus type 1-specific CD8 responses in perinatally infected children.
Journal of virology
Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection.
The Journal of clinical investigation